Building a DNA Assembler in Haskell: 5 Algorithmic Insights
A Puzzle Without a Picture Genome sequencing faces a fundamental physical constraint: modern instruments cannot read a long chromosome continuously from end to end. Instead, they synthesise or capture millions of short sequence fragments called reads. These range from 150 base pairs in high-throughput short-read chemistry to tens of thousands of base pairs on long-read instruments—and well over a million base pairs with Oxford Nanopore ultra-long protocols. Reconstructing a complete genome from these fragments is like solving a multi-million-piece jigsaw puzzle without the picture on the box top. To tackle this challenge, I turned to graph-theoretical assembly frameworks. The Overlap-Layout-Consensus (OLC) paradigm is one of the classic, most intuitive ways to stitch fragments into continuous sequences called contigs. While building reconstruct-strings —a pure and total Haskell implementation of a greedy OLC assembler—I set out to explore sequence reconstruction from first princ...